Anal oxycontin insertion
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Oxycodone Suppository - Rectal
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Asian Pac J Cancer Prev. ;12(10) Clinical observations on safety and efficacy of OxyContin® administered by rectal route in treating cancer related .
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Description:Administering medication rectally Glycerin laxative suppositories for insertion into the rectum. Rectal administration uses the rectum as a route of administration for medication and other fluids, which are absorbed by the rectum's blood vessels , [Note 1] and flow into the body's circulatory system , which distributes the drug to the body's organs and bodily systems. In addition, the rectal route bypasses around two thirds of the first-pass metabolism as the rectum's venous drainage is two thirds systemic middle and inferior rectal vein and one third hepatic portal system superior rectal vein. This means the drug will reach the circulatory system with significantly less alteration and in greater concentrations. Unlike intravenous lines, which usually need to be placed in an inpatient environment and require special formulation of sterile medications, [3] a specialized rectal catheter can be placed by a clinician, such as a hospice nurse or home health nurse, in the home.
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