Progesterone effect function sperm caused
Progesterone stimulates sperm functions, e.g. hyperactivation, acrosome . followed by antibody anti-progesterone, which causes receptor aggregation.
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What does Progesterone do?
Mar 25, Progesterone causes elevation of sperm intracellular Ca2+ leading to sperm .. and effect of seminal fluid on sperm ion channel function.
Description:This article has been cited by other articles in PMC. Abstract The female steroid hormone progesterone regulates ovulation and supports pregnancy, but also controls human sperm function within the female reproductive tract. Moreover, it is not clear whether the responsiveness of CatSper to progesterone is an innate property of human spermatozoa or is acquired as the result of exposure to the seminal plasma. In addition, by recording CatSper currents from human epididymal and testicular spermatozoa, we show that CatSper sensitivity to progesterone arises early in sperm development and increases gradually to a peak when spermatozoa are ejaculated. These results unambiguously establish an important role of CatSper channel in human sperm nongenomic progesterone signaling and demonstrate that the molecular mechanism responsible for activation of CatSper by progesterone arises early in sperm development concurrently with the CatSper channel itself.
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