Mercaptopurine sperm donation

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Azathioprine/6-Mercaptopurine in This study was supported by a grant from the Edythe and Eli Broad that may not affect ability of sperm to fertilize ovum.

Scand J Gastroenterol. Apr;40(4) Effects of 6-mercaptopurine treatment on sperm production and reproductive performance: a study in male mice.

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Description:Azathioprine and 6-mercaptopurine interact in purine metabolism and DNA synthesis, thus their potential mutagenic effects have been of concern in the management of inflammatory bowel disease IBD , especially in patients of childbearing age. Although several clinical studies have indicated their safety in both reproduction and pregnancy, in a recent large epidemiological study concerns were raised about their adverse effects in pregnant patients with IBD, and experimental or basic data on this subject are limited. The aim of this study was to investigate sperm production, sperm quality, and reproductive outcome following prolonged 6-MP administration to male mice.

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