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J Appl Physiol (). Feb;92(2) Sexually dimorphic effects of morphine and MK sex steroid-dependent and -independent mechanisms.

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Rats show gender differences in responses to morphine and the N-methyl-D- aspartate receptor antagonist dizocilpine (MK); the role of sex steroids in.

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Description:Abstract Rats show gender differences in responses to morphine and the N-methyl-D-aspartate receptor antagonist dizocilpine MK ; the role of sex steroids in mediating these differences is unclear. We tested the overall hypothesis that circulating gonadal steroids determine the gender differences in morphine- and MKinduced behavior and c-Fos expression. Morphine caused a greater expression of c-Fos in the striatum of intact males than of that females, which was independent of sex steroids.

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